Isocucurbitacin D( —— )

Catalog No. M32270 CAS No. 68422-20-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Isocucurbitacin D
Note

Research use only, not for human use.
Brief Description

Isocucurbitacin D showed a cytotoxic effect with disruption of target protein cofilin.
Description

Isocucurbitacin D showed a cytotoxic effect with disruption of target protein cofilin. Isocucurbitacin D exhibited the highest activities of improved the LDL uptake rate.Isocucurbitacin D dose-dependently increased LDLR protein levels and decreased PCSK9 protein levels.
In Vitro

Isocucurbitacin D inhibits tumor cell growth with ED50s of 0.06, 0.2, 0.6, 0.8 and 1.2 μg/mL against SK-MEL-2, A549, XF498, HCT15 and SK-OV-3 cells, respectively. Cell Proliferation Assay Cell Line:MCF-7, MDA MB 231, A2780, A2780 CP, HepG2 and HCT-116 cells Concentration:0-100 μM Incubation Time:48 h Result:Inhibited cell proliferation with IC50s of 12.0, 30.7, 37.8, 47.9, >100 and >100 μM against MDA MB 231, HCT-116, HepG2, MCF-7, A2780 and A2780 CP, respectively.
In Vivo

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Synonyms

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Pathway

Others
Target

Other Targets
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Indication

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1.J Nat Prod., 2020 Dec 24;83(12):3536-3544.

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